Process Engineer iPSC-based Cell Therapy R&D

As a process engineer in hiPSC-based Process Development your key responsibilities will be in developing suspension-based and/or adherent culture manufacturing processes. In this role you will focus on the automation and scale-up of bioprocesses for manufacturing products from pluripotent stem cells to include but not limited to immunotherapy, CAR-T, and NK cells. You will also provide technical expertise in cGMP cell manufacturing including bioreactors, cell washing and concentration technologies, and fill/finish operations.

You are self-motivated and energetic with a strong focus on innovation, and critical thinking, and with experience in a service organization or demonstrable soft skills that are needed for commercial projects. As part of the job responsibility includes hands-on processes development, the preferred candidate is a motivated researcher with desire to work in a laboratory, including occasional cell maintenance during the weekend.

Responsibilities

• Lead and deliver process optimization studies focused on scale-up of novel hiPSC-derived cell types according to defined timelines, budget and milestones. Customer sponsored projects are part of the position
• Evaluate and implement technologies to improve consistency, increase scale, and facilitate cGMP compliance of bioprocesses for manufacturing hiPSC-derived therapeutics
• Develop scale-down models for process optimization studies
• Evaluate and implement process analytical technologies (PAT) for improved monitoring and control of stem cell bioprocesses
• Ensure accurate internal data reporting
• Contribute to or lead scientific presentations and collaboration with external stakeholders
• Write protocols, technical reports, and Standard Operating Procedures (SOPs)
• Collaborate with project teams to integrate processes
• Participate in technology transfer of processes and equipment to the Manufacturing group

Qualifications

• Ph.D. in biology, bio-engineering, or other relevant discipline and/or relevant equivalent working experience
• Demonstrated proficiency in mammalian cell culture processes - preferably with bioreactors
• Relevant experience or understanding of the following:
  • Process development as a member of product/process development teams
  • QbD/DE approaches
  • cGMP biomanufacturing
  • Pluripotent stem cells and/or differentiation
  • Immuno-biology, immuno-therapy, and related manufacturing techniques
• Attention to detail, and problem-solving
• Excellent organization, project, and time management skills. Timelines may be demanding
• Capacity to innovate and contribute to company IP
• Good communicator and team-player
• Can maintain flexibility in a dynamic environment
• Proficiency in English, both written and spoken

Job Location: Mont Saint Guibert, Belgium

Position Type: Full-Time

Start Date: Immediately

We offer you a challenging position in a dynamic biotech company with room for personal growth and development. We provide a competitive salary package based on your education and experience.

Interested?

Send your motivation letter with curriculum vitae to: careers@cellistic.com